Blar i forfatter "Ravna, Aina W."

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    • Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure 

      Ravna, Aina W.; Sylte, Ingebrigt; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-09-04)
      The human ATP-binding cassette (ABC) transporters ABCB1, ABCC4 and ABCC5 are involved in resistance to chemotherapeutic agents. Here we present molecular models of ABCB1, ABCC4 and ABCC5 by homology based on a wide open inward-facing conformation of <i>Escherichia coli</i> MsbA, which were constructed in order to elucidate differences in the electrostatic and molecular features of their drug ...

    • Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5) 

      Ravna, Aina W.; Sylte, Ingebrigt; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2007-09-06)
      Background: Multidrug resistance is a particular limitation to cancer chemotherapy, antibiotic treatment and HIV medication. The ABC (ATP binding cassette) transporters human P-glycoprotein (ABCB1) and the human MRP5 (ABCC5) are involved in multidrug resistance. Results: In order to elucidate structural and molecular concepts of multidrug resistance, we have constructed a molecular model of the ...